Why do you feel like you are somebody experiencing life? Is your sense of self simply a product of brain activity or are “you” something more? In this course, we will explore historical and modern interpretations of self in the contexts of biology, society, and philosophy. An introduction to nervous system anatomy and physiology provides a foundation for the exploration of the roles of the cerebral cortex and thalamus, the gut-brain axis, and the immune system in the experience of self. Working independently and collaboratively to conduct research and experiments on these concepts, we will develop an understanding of what self is.